Israeli Prime Minister Benjamin Netanyahu is on the mission of his lifetime. For years, the veteran leader has made the destruction of Iran’s nuclear program his top priority.

DUBAI, United Arab Emirates (AP) — Israel unleashed airstrikes across Iran for a third day on Sunday and threatened even greater force as some Iranian missiles evaded Israeli air defenses to strike buildings in the heart of the country. Planned talks on Iran’s nuclear program, which could provide an off-ramp, were canceled.

A sixth round of nuclear talks between the United States and Iran, previously scheduled for Sunday, was canceled amid escalating tensions between Israel and Iran.

In Israel, at least 10 people were killed in Iranian strikes overnight and into Sunday, according to the Magen David Adom rescue service, bringing the country’s total death toll to 13. The country’s main international airport and airspace remained closed for a third day.

The retaliatory strikes came on Saturday, a day after Israel killed top Iranian military leaders and scientists and destroyed an aboveground nuclear enrichment plant near Natanz.